From Central New York (I-90):

Exit 31 off New York Thruway (Route 90) at Utica. Follow Route 12 North to Alder Creek (25 miles). Fork Right to Route 28 North. Follow 28N through Old Forge to Inlet (38 miles). Continue 1 1/4 miles north on Route 28. Veer left at intersection of Seventh Lake Road and Route 28. Clayton's is adjacent to Drake's Inn on the left.  The office will be on your right. 

From Albany and the Northway (I-87):

Exit 23 off Adirondack Northway (Route 87) at Warrensburg, turn left and cross over Route 87. Turn right on Route 9 North. Follow Route 9 through village (6-7 miles). Fork left to Route 28 North (opposite motel and auto body shop). Follow to Blue Mountain Lake. Take left to Route 28 West (follow signs to Old Forge). Travel another 22 miles toward Old Forge and Inlet. Pass Deer Meadows Motel on left, and at the end of a long straightaway approaching Drake's Inn on right, take a sharp right at the intersection of Route 28 and the Seventh Lake road into Clayton's entrance.  The office will be on your right.

From Canada via the 1000's Islands Bridge and Watertown ( I -81):

South on I - 81 to Watertown and then continue south on Route 12 to Alder Creek.  Turn North on Route 28 passing through Old Forge.  Follow 28 N through Inlet.  Continue 1 1/4 miles north on Route 28. Veer left at intersection of Seventh Lake Road and Route 28. Clayton's is adjacent to Drake's Inn on the left.  The office will be on your right.

South on I -87 to Exit 29.  Take Route 2 West turning right on Route 28 N traveling through Newcomb and  Long Lake. Follow on to Blue Mountain Lake.  Stay straight on 28 West towards Old Forge.  Travel another 22 miles toward Old Forge and Inlet. Pass Deer Meadows Motel on left, and at the end of a long straightaway approaching Drake's Inn on right, take a sharp right at the intersection of Route 28 and the Seventh Lake Road into Clayton's entrance.  The office will be on your right.